Image: Overview of cellular respiration stages — Wikimedia Commons (public domain)
Conceptual Flow
Comparative Summary Table
| Feature | Glycolysis | Link Reaction | TCA Cycle | ETS |
|---|---|---|---|---|
| Location | Cytoplasm | Mito. matrix | Mito. matrix | Inner mito. membrane |
| needed? | No | No | No (indirect) | Yes (final acceptor) |
| ATP produced (direct) | 2 ATP | 0 | 2 GTP | 34 ATP |
| NADH produced | 2 | 2 | 6 | 0 (consumed) |
| produced | 0 | 0 | 2 | 0 (consumed) |
| released | 0 | 2 | 4 | 0 |
RQ Visual Reference
| Substrate | RQ Value | Visual Cue |
|---|---|---|
| Carbohydrates (glucose) | 1.0 | Equal gases; perfectly balanced |
| Fats (tripalmitin) | ~0.7 | "Low" — fat needs more |
| Proteins | ~0.8 | Middle value |
| Organic acids (malic) | ~1.33 | "High" — already oxidised |
| CAM plants (night) | ∞ | Off the chart — no external |
Key Structural Landmark: Mitochondrion
The mitochondrion is the powerhouse of aerobic respiration. Its double-membrane structure is functionally critical:
- Outer membrane: Permeable to small molecules; not involved in ATP synthesis
- Intermembrane space: Accumulates during ETS — high [], low pH
- Inner membrane (cristae): Site of ETS complexes (I–IV) and ATP synthase; highly folded to maximise surface area
- Matrix: Site of TCA cycle and link reaction; contains TCA enzymes and mtDNA