Part of BIO-01 — Human Health & Disease

Human Health & Disease: Key Numbers & Data

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Fever cycle intervals in malaria:

  • P. vivax (benign tertian): fever every 48 hours
  • P. falciparum (malignant tertian): fever every 48 hours (sometimes irregular; most dangerous)
  • P. malariae (quartan): fever every 72 hours

Immunoglobulin classes (5 types — "GAMED"):

  • IgG — most abundant (~75% of serum Ig); crosses placenta; long half-life (~23 days)
  • IgA — secretory antibody in colostrum, saliva, tears, mucosa
  • IgM — largest antibody (pentamer); first produced in primary immune response
  • IgE — least abundant; involved in allergy and anti-parasitic response
  • IgD — B-cell surface receptor; least well-characterised

Diagnostic tests for key diseases:

  • Typhoid: Widal test
  • HIV/AIDS: ELISA (screen) → Western blot (confirm)
  • Malaria: blood smear (peripheral blood film) / rapid diagnostic test (RDT)
  • Amoebiasis: stool microscopy
  • Filariasis: blood smear for microfilariae (nocturnal periodicity)

Drug sources — botanical:

  • Heroin (diacetylmorphine): Papaver somniferum (opium poppy)
  • Cocaine: Erythroxylum coca
  • Cannabinoids (THC): Cannabis sativa
  • Nicotine: Nicotiana tabacum

Tumour suppressor genes tested in NEET:

  • p53 (chromosome 17) — "guardian of the genome"
  • Rb (retinoblastoma gene, chromosome 13)

HIV classification:

  • Family: Retroviridae; Genus: Lentivirus
  • Key enzyme: reverse transcriptase
  • Target receptor: CD4 (also CCR5/CXCR4 co-receptors)

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