Part of GEN-02 — Chromosomal Basis of Inheritance, Sex Linkage & Genetic Disorders

Worked Problem Note — Probability Calculations

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Problem 1: Standard Haemophilia Cross

Given: Carrier female (XHX^H XhX^h) × Normal male (XHX^H Y) Find: (a) P(haemophilic son) (b) P(haemophilic child) (c) P(carrier daughter)

Step-by-step:

  1. Draw Punnett square:

    • Female gametes: XHX^H, XhX^h
    • Male gametes: XHX^H, Y
    • Offspring: XHX^H XHX^H (25%), XHX^H XhX^h (25%), XHX^H Y (25%), XhX^h Y (25%)
  2. (a) P(haemophilic | son): Sons are XHX^H Y and XhX^h Y (50% each among sons). P(haemophilic son) = 1/2 of sons

  3. (b) P(haemophilic child) overall: Only XhX^h Y = 25% = 1/4 of all children

  4. (c) P(carrier daughter): XHX^H XhX^h daughters = 25% of all children = 1/2 of all daughters

Answer: (a) 1/2 of sons; (b) 1/4 of all children; (c) 1/2 of daughters

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