Part of CB-03 — Cell Cycle, Mitosis & Meiosis

Timeline: Discovery History of Cell Division Knowledge

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YearScientist(s)Discovery / Contribution
1838–1839Schleiden & SchwannCell theory: all organisms made of cells; cells arise from pre-existing cells (Virchow, 1855)
1842Carl NägeliFirst described cell division in plant cells microscopically
1873Anton SchneiderFirst described mitosis and chromosome movements in animal cells
1879Walther FlemmingNamed "mitosis" and described chromatin; observed chromosome splitting in anaphase
1882Walther FlemmingPublished "Zellsubstanz, Kern und Zelltheilung" — systematic description of mitosis
1887August WeismannPredicted the necessity of a reductional division for sexual reproduction (before meiosis was described)
1888Eduard StrasburgerDescribed mitosis in plant cells; Wilhelm Waldeyer coined term "chromosome"
1890Theodor BoveriDescribed the continuity of chromosomes; proposed their role in heredity
1900E.L. Mark & othersIndependent descriptions of meiosis in various organisms
1900–1902Farmer & MooreCoined the term "meiosis" (from Greek "meioun" = to lessen)
1903Walter Sutton & Theodor BoveriChromosome theory of heredity — chromosomes carry genes; meiosis explains Mendelian ratios
1951Howard & PelcDemonstrated discrete phases of the cell cycle; coined S phase terminology using autoradiography
1970sMazia, Hartwell, Nurse, HuntDiscovery of cell cycle regulation, MPF (Maturation Promoting Factor), cyclins, CDKs
2001Nobel PrizeHartwell, Hunt, and Nurse awarded Nobel for discoveries in cell cycle control

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