Part of JOC-07 — Biomolecules: Carbohydrates, Amino Acids, Nucleic Acids

Nucleosides vs Nucleotides — Nomenclature

by Notetube Official121 words5 views

Nucleoside = nitrogenous base + pentose sugar (N-glycosidic bond between N9 of purine or N1 of pyrimidine and C1' of sugar). No phosphate group.

Nucleotide = nucleoside + phosphate group(s) esterified to the 5' carbon of the sugar. Nucleotides are the monomers of nucleic acids.

Naming convention:

  • DNA nucleosides: Deoxyadenosine, deoxyguanosine, deoxycytidine, thymidine
  • RNA nucleosides: Adenosine, guanosine, cytidine, uridine
  • Add "5'-monophosphate" for nucleotide: Adenosine 5'-monophosphate = AMP

ATP (adenosine triphosphate): Contains adenine + ribose + 3 phosphate groups. The "energy currency" of cells. Hydrolysis of terminal phosphoanhydride bond: ATP → ADP + Pi releases approximately 30.5 kJ/mol under standard conditions.

Cyclic AMP (cAMP): 3',5'-cyclic AMP — important secondary messenger in hormone signaling. Formed from ATP by adenylyl cyclase.

Like these notes? Save your own copy and start studying with NoteTube's AI tools.

Sign up free to clone these notes