Overall Equation
$C_{6}H_{12}O_{6}$ + $6O_{2}$ → $6CO_{2}$ + $6H_{2}O$ + 38 ATP
ATP Balance Sheet (Per Glucose)
| Stage | Direct ATP | NADH → ATP | → ATP | GTP → ATP | Stage Total |
|---|---|---|---|---|---|
| Glycolysis | 2 ATP (net) | 2 × 3 = 6 | — | — | 8 |
| Oxidative decarboxylation | 0 | 2 × 3 = 6 | — | — | 6 |
| TCA cycle (×2 turns) | 0 | 6 × 3 = 18 | 2 × 2 = 4 | 2 | 24 |
| Grand Total | 2 | 30 | 4 | 2 | 38 |
Note: If glycerol-3-phosphate shuttle is used → cytoplasmic 2 NADH yield 4 ATP (not 6) → total = 36 ATP
RQ Values
| Substrate | RQ | Formula used |
|---|---|---|
| Carbohydrates (glucose) | 1.0 | + → + ; RQ = 6/6 |
| Fats (tripalmitin) | ~0.7 | Long hydrocarbon chains need more |
| Proteins | ~0.8 | Intermediate oxidation state |
| Organic acids (malic acid) | ~1.33 | + 3 → 4C + ; RQ = 4/3 |
| CAM plants (night) | ∞ | C fixed internally; consumed, no external C released |
| Germinating fatty seeds | <1 → 1 | Fats first, then carbohydrates |
NADH vs ATP Yield
- NADH → 3 ATP (enters at Complex I; pumps through Complexes I, III, IV)
- → 2 ATP (enters at Complex II; bypasses Complex I; only Complexes III, IV pump )
Key Cofactors
- Pyruvate dehydrogenase complex: TPP (thiamine pyrophosphate), N, CoA
- RQ formula: RQ = Volume C evolved / Volume consumed
Key Ions
- (protons): Drive ATP synthase via chemiosmosis
- /: In cytochrome proteins (electron carriers)
- : Cofactor for hexokinase and other glycolytic enzymes