TOP 10 MUST-KNOW FACTS (Review 30 minutes before exam)
- Bile has ZERO enzymes — bile SALTS only emulsify fats. Pancreatic lipase digests fats.
- Enterokinase = DUODENAL MUCOSA (NOT pancreas) → activates trypsinogen → trypsin → all other proenzymes
- Fats → LACTEALS → thoracic duct → subclavian vein (bypass liver). Glucose/amino acids → blood capillaries → portal vein → liver.
- Large intestine = water + minerals ONLY (no glucose, no amino acids, no fat absorbed). Bacteria → vitamins B + K.
- Kwashiorkor = oedema (protein deficiency → low albumin → low oncotic pressure). Marasmus = wasting (total calorie deficiency, NO oedema).
- HCl activates pepsinogen → pepsin (in stomach). Enterokinase activates trypsinogen → trypsin (in duodenum). Different enzymes, different locations.
- Villi + microvilli = 600-fold surface area amplification in small intestine.
- CCK = bile + enzymes (gallbladder + pancreatic acinar cells). Secretin = bicarbonate only (pancreatic ductal cells). Never confuse these two.
- Glucose absorption = active transport (SGLT) + gradient in jejunum. Not passive, not lacteals.
- Rugae = stomach (expansion); Villi = small intestine (absorption); Haustra = large intestine (sacculations). Each organ has ONE unique structural feature.
TOP 5 NUMBERS/VALUES (Must Memorize Exactly)
| Value | Number |
|---|---|
| Salivary amylase optimal pH | 6.8 |
| Pepsin optimal pH | 1.5–2.0 |
| Trypsin/Chymotrypsin optimal pH | 7.5–8.5 |
| Surface area amplification by villi + microvilli | ~600-fold |
| Bile salts recycled in enterohepatic circulation | ~95% |
TOP 3 NEET TRAPS (Never Fall For These)
Trap 1: "Bile contains lipase that digests fats"
- ALWAYS WRONG. Bile has NO enzymes. Lipase is pancreatic.
Trap 2: "Enterokinase is secreted by the pancreas"
- ALWAYS WRONG. Enterokinase is from the duodenal mucosa (intestinal).
Trap 3: "Glucose/amino acids are absorbed into lacteals"
- ALWAYS WRONG. Only FATS (as chylomicrons) go into lacteals. Glucose + amino acids → blood capillaries.
4-Hormone Quick Reference
| Hormone | Source Cell | Trigger | Action |
|---|---|---|---|
| Gastrin | G-cells (pyloric stomach) | Proteins in stomach | HCl + pepsinogen ↑ |
| Secretin | S-cells (duodenum) | Acidic chyme in duodenum | Pancreatic bicarbonate ↑ |
| CCK | I-cells (duodenum) | Fats + amino acids in duodenum | Bile release + pancreatic enzymes ↑ |
| GIP | K-cells (duodenum) | Fats + glucose in duodenum | Gastric acid ↓ + Insulin ↑ |