| Bowman's capsule | Cortex | Encapsulates glomerulus; receives filtrate (ultrafiltration) |
| Glomerulus | Cortex (within Bowman's capsule) | High-pressure capillary tuft; site of blood ultrafiltration |
| PCT | Cortex | Bulk reabsorption (65–70%): glucose, AA, Na+, water (obligatory) |
| Descending Limb | Medulla (entering) | Water exits by osmosis (water-permeable, solute-impermeable) |
| Loop Tip | Inner medulla | Tubular fluid most concentrated (~1200 mOsm/L in JM nephrons) |
| Ascending Limb | Medulla (leaving) | NaCl actively pumped out; water-impermeable; fluid dilutes |
| DCT | Cortex | Facultative reabsorption: Na+ (aldosterone), water (ADH), Ca2+ (PTH) |
| Collecting Duct | Cortex → medulla | Final water reabsorption under ADH; urea recycling |
| Vasa Recta | Medulla (parallel to loop) | Counter-current exchanger; preserves medullary osmotic gradient |
| Juxtaglomerular Apparatus | Where DCT meets afferent arteriole | Renin release; blood pressure and NaCl sensing |