Part of GEN-01 — Mendelian Genetics & Inheritance Patterns

Cornell Note — Monohybrid Cross Deep Dive

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Cue Column | Note Column

Question | Answer

F1 genotype of TT × tt? | All Tt (heterozygous). All phenotypically tall (dominant).

F2 from Tt × Tt? | Phenotypic ratio: 3 Tall : 1 Dwarf. Genotypic ratio: 1 TT : 2 Tt : 1 tt.

Why 3:1 phenotypic but 1:2:1 genotypic? | TT and Tt are phenotypically indistinguishable (both tall). Genotypically distinct. In incomplete dominance, all three genotypes differ phenotypically → ratio is 1:2:1 for both.

Punnett Square (Tt × Tt):

Tt
TTT (Tall)Tt (Tall)
tTt (Tall)tt (Dwarf)

How does test cross work? | TT × tt → all Tt (all tall). Tt × tt → 1 Tt : 1 tt (1 tall : 1 dwarf). The 1:1 ratio reveals heterozygosity.

Summary

The monohybrid cross demonstrates both Law of Dominance (F1 all dominant) and Law of Segregation (F2 returns 3:1). The distinction between phenotypic (3:1) and genotypic (1:2:1) ratios depends on whether the heterozygote is phenotypically distinguishable. Test cross (with tt) is the diagnostic for unknown dominant genotypes.

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