| Waste product | Ammonia (NH3) | Urea | Uric acid |
| Toxicity | Highest — disrupts enzymes and neurons | Moderate | Lowest — nearly non-toxic |
| Solubility | Highly soluble | Soluble | Nearly insoluble |
| Water needed | Most (constant flushing required) | Moderate | Least (semi-solid paste) |
| Physical form of excretion | Liquid (dissolved, highly dilute) | Liquid (dissolved in urine) | Semi-solid paste |
| Energy cost | Least (direct excretion, no conversion) | Moderate (ornithine cycle: ~4 ATP/molecule) | Most (complex synthesis pathway) |
| Habitat adaptation | Aquatic — water abundant | Terrestrial/semi-aquatic | Strictly terrestrial; cleidoic eggs |
| Examples | Bony fishes, aquatic amphibians (tadpoles), aquatic insects | Mammals, terrestrial amphibians (adult frogs), marine fishes, turtles | Birds, reptiles, land snails, terrestrial insects |
| NEET trap | Marine fish are NOT ammonotelic | Adult frog is ureotelic (not tadpole) | Insects listed here are terrestrial insects |
| Advantage | Energetically cheapest | Balances toxicity and water use | Maximum water conservation |